Recombinant Human BAG2 Protein (His Tag)
Product Specifications
Background
BAG Family Molecular Chaperone Regulator 2 (BAG2) is a member of the Bag family whose members compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. BAG2 contains 1 BAG domain and is a important component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex. In mammalian cells BAG1, BAG2, and BAG3 bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Abbreviation
BAG2
Synonyms
BAG Family Molecular Chaperone Regulator 2; BAG-2; BAG2; Bcl-2-Associated Athanogene 2
UniProt
O95816
Accession Number
O95816
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Asn211
Field of Research
Signal Transduction; Cell biology; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
25.9 kDa
Observed Molecular Weight
25-30 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM EDTA, 1mM DTT, 10% Glycerol, pH8.0.
Species
Human
Available Sizes
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