Recombinant Human BCAS2/DAM1 Protein (His & T7 Tag)

Product Specifications

Background

Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed in various breast cancer cell lines. BCAS2 is a component of the spliceosome, taking part in the removal of introns from mRNA precursors. BCAS2 interacts with estrogen receptor alpha and beta, thyroid hormone receptor beta, peroxisome proliferator-activated receptor gamma. BCAS2 functions as an ER co-activator and is capable of enhancing ER-mediated transcription.

Abbreviation

BCAS2; DAM1

Synonyms

BCAS2; Breast Carcinoma-Amplified Sequence 2; DAM1; DNA Amplified in Mammary Carcinoma 1 Protein; Pre-mRNA-Splicing Factor SPF27; Spliceosome-Associated Protein SPF 27

UniProt

O75934

Accession Number

O75934

Expression System

E.coli

Tag

N-T7 & C-His

Sequence

Ala2-Phe225

Field of Research

Tags & Cell Markers; epigenetics and nuclear signal

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.