Recombinant Human Survivin/BIRC5 Protein
Product Specifications
Background
Baculoviral IAP Repeat-Containing Protein 5 (BIRC5) belongs to the IAP family. BIRC5 exists as a homodimer in the apo state and as a monomer in the CPC-bound state. BIRC5 contains one BIR repeat and is expressed only in fetal kidney and liver, and to lesser extent, lung and brain. BIRC5 functions as a multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis. BIRC5 is also a component of a chromosome passage protein complex (CPC), which is essential for chromosome alignment and segregation during mitosis and cytokinesis. BIRC5 acts as an important regulator of the localization of this complex.
Abbreviation
Survivin; BIRC5
Synonyms
API4; Apoptosis Inhibitor 4; Apoptosis Inhibitor Survivin; BIRC5; Baculoviral IAP Repeat-Containing Protein 5; IAP4
UniProt
O15392
Accession Number
O15392
Expression System
E.coli
Tag
None
Sequence
Met 1-Asp142
Field of Research
Cell biology; Neuroscience; Cancer
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/qm9gck
Product MSDS
https://789.bio/eb/P04uv9
Calculated Molecular Weight
16.4 kDa
Observed Molecular Weight
16-18 kDa
Species
Human
Available Sizes
Curated Selection
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