Recombinant Human Arylsulfatase A/ARSA Protein (His Tag)
Product Specifications
Background
Arylsulfatase A (ARSA) is a lysosomal enzyme that breaks down Cerebroside 3-Sulfate, a major constituent of the myelin sheet, into Cerebroside and Sulfate. The ARSA deficiency results in Metachromatic Leukodystrophy (MLD), a lysosomal storage disease in the central and peripheral nervous systems with severe and progressive neurological symptoms. Recombinant Human ARSA corresponds to the ARSA mature peptide and has sulfatase activity.
Abbreviation
Arylsulfatase A; ARSA
Synonyms
ARSA; ASA; Arylsulfatase A; Cerebroside-Sulfatase
UniProt
P15289
Accession Number
AAH14210.2
Expression System
HEK293 Cells
Tag
C-His
Sequence
Arg19-Ala507
Field of Research
Signal Transduction; Tags & Cell Markers; Cell biology; Neuroscience; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
52.9 kDa
Observed Molecular Weight
50-65 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 300mM NaCl, pH 8.0.
Species
Human
Available Sizes
Documents
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