Recombinant Human APE1/APE Protein
Product Specifications
Background
Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the DNA glycosylase remove the damaged bases; APE1 cleaves the AP site to allow resynthesis and ligation to complete repair. APE1 stimulates the DNA binding activity of many transcription factors; which participate in cancer promotion and progression. APE1 regulates the redox state of multiple transcription factors; such as c-Jun; c-Fos; NF-kB; p53. APEN is also involved in calcium-dependent down-regulation of PTH expression.
Abbreviation
APE1; APE
Synonyms
AP Endonuclease 1; APE; APE-1REF-1; APE1; APEN; APEX; APEX Nuclease; APEX1; APX; Apurinic-Apyrimidinic Endonuclease 1; DNA- (Apurinic or Apyrimidinic Site) Lyase; HAP1; REF1; Redox Factor-1
UniProt
P27695
Accession Number
AAH02338.1
Expression System
E.coli
Tag
None
Sequence
Pro2-Leu318
Field of Research
Cardiovascular; epigenetics and nuclear signal
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
35.6 kDa
Observed Molecular Weight
40 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4.
Species
Human
Available Sizes
Documents
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