Recombinant Human Apolipoprotein C-II/APOC2 Protein (His Tag)
Product Specifications
Background
APOC2 activates the lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. APOC2 is component of the very low density lipoprotein (VLDL) fraction in plasma. It is also an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoproteinemia type 1B (HLPP1B) which characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.
Abbreviation
Apolipoprotein C-II; APOC2
Synonyms
APC2 and APOC2; Apolipoprotein C-II; Apolipoprotein C2
UniProt
P02655
Accession Number
AAP35354.1
Expression System
E.coli
Tag
C-His
Sequence
Thr23-Glu101
Field of Research
Signal Transduction; Cardiovascular; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
10.0 kDa
Observed Molecular Weight
14 kDa
Formulation
Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.
Species
Human
Available Sizes
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