Recombinant Human ACE2 Protein (His Tag)

Product Specifications

Background

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.

Abbreviation

ACE2

Synonyms

ACE-Related Carboxypeptidase; ACE2; ACEH; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Homolog; Metalloprotease MPROT15

UniProt

Q9BYF1

Accession Number

Q9BYF1

Expression System

HEK293 Cells

Tag

C-His

Sequence

Gln18-Ser740

Applications

BLI

Field of Research

Cell biology; Cardiovascular

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method.

Purity

> 95 % as determined by reducing SDS-PAGE.

Bioactivity

Loaded 2019-nCoV S Protein RBD-mFc on AMC Biosensor, can bind Human ACE-2-His with an affinity constant of 2.06 nM as determined in BLI assay.

Reconstitution

Not Applicable

Shipping Conditions

This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Storage Conditions

Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Calculated Molecular Weight

84.6 kDa

Observed Molecular Weight

103 kDa

Formulation

Citation 01

https://www.mdpi.com/1844936

Species

Human

Available Sizes

Documents

Product Datasheet

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