Recombinant Human AKR1C4 Protein (His Tag)
Product Specifications
Background
Aldo-Keto Reductase 1C4/AKR1C4 is a member of the aldo/keto reductase family that consists of more than 40 known enzymes and proteins. AKR1C4 has highly expressed in Liver. It can catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. AKR1C4 catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-α-Androstan-3-α,17-β-diol (3-α-diol) . In addition, AKR1C4 also has some 20-α-Hydroxysteroid Dehydrogenase activity.
Abbreviation
AKR1C4
Synonyms
3-Alpha-HSD1;3-Alpha-Hydroxysteroid Dehydrogenase Type I; AKR1C4; Aldo-Keto Reductase Family 1 Member C4; CDR; CHDR; Chlordecone Reductase; DD-4; DD4; Dihydrodiol Dehydrogenase 4; HAKRA
UniProt
P17516
Accession Number
P17516
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Tyr323
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
39.3 kDa
Observed Molecular Weight
35-40 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Species
Human
Available Sizes
Curated Selection
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