Recombinant Human AKR1C3 Protein (His Tag)
Product Specifications
Background
AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2, which functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. It can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites.
Abbreviation
AKR1C3
Synonyms
17-Beta-HSD 5;17-Beta-Hydroxysteroid Dehydrogenase Type 5;3-Alpha-HSD Type 2;3-Alpha-HSD Type II Brain;3-Alpha-Hydroxysteroid Dehydrogenase Type 2; Aldo-Keto Reductase Family 1 Member C3; Chlordecone Reductase Homolog HAKRb; DD-3; Dihydrodiol Dehydrogenase 3
UniProt
P42330
Accession Number
P42330
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-Tyr323
Field of Research
Signal Transduction; Neuroscience; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/skpdxp
Product MSDS
https://789.bio/eb/8WffLS
Calculated Molecular Weight
37.9 kDa
Observed Molecular Weight
38 kDa
Species
Human
Available Sizes
Curated Selection
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