Recombinant Human AKR1C2 Protein
Product Specifications
Background
Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation of the most potent androgen 5-α-Dihydrotestosterone (5-α-DHT) to 5-α-Androstane-3-α, 17-β-diol (3-α-diol) .
Abbreviation
AKR1C2
Synonyms
2-Dihydrobenzene-1;2-Diol Dehydrogenase;3-Alpha-HSD3; Aldo-Keto Reductase Family 1 Member C2; Chlordecone Reductase Homolog HAKRD; DD-2; DD/BABP; DD2; Dihydrodiol Dehydrogenase 2; Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein; Trans-1; Type III 3-Alpha-Hydro
UniProt
P52895
Accession Number
P52895
Expression System
E.coli
Tag
None
Sequence
Met 1-Tyr323
Field of Research
Signal Transduction; Cancer; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
36.7 kDa
Observed Molecular Weight
35 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, 1mM DTT, pH 8.0.
Species
Human
Available Sizes
Curated Selection
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