Recombinant Human ALDH1A1/ALDC Protein (His Tag)
Product Specifications
Background
Aldehyde Dehydrogenase Family 1 Member A1 (ALDH1A1) is a cytoplasmic enzyme that belongs to the Aldehyde Dehydrogenase family. ALDH1A1 is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties and subcellular localizations. ALDH1A1 is the main cytosolic isoform, which has a lower affinity for aldehydes than the mitochondrial enzyme. ALDH1A1 binds free retinal and cellular retinol-binding protein-bound retinal. It can convert/oxidize retinaldehyde to retinoic acid.
Abbreviation
ALDH1A1; ALDC
Synonyms
ALDC; ALDH-E1; ALDH1; ALDH11; ALDH1A1; ALHDII; Aldehyde Dehydrogenase Cytosolic; Aldehyde Dehydrogenase Family 1 Member A1; HEL-9; HEL-S-53e; HEL12; PUMB1; PUMB10; RALDH 1; RALDH1; RalDH1; Retinal Dehydrogenase 1
UniProt
P00352
Accession Number
P00352
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Ser501
Field of Research
Neuroscience; Cancer; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
57.0 kDa
Observed Molecular Weight
60 kDa
Formulation
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 20% Glycerol, 1mM DTT, pH 8.0.
Species
Human
Available Sizes
Documents
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