Recombinant Human TGFB1/TGF-beta 1 Protein
Product Specifications
Background
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone; articular cartilage and chondrocytes and is increased in osteoarthritis (OA) . TGFβ-1 performs many cellular functions; including the control of cell growth; cell proliferation; cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Abbreviation
TGFB1; TGF-beta 1
Synonyms
CED; DPD1; LAP; Latency-Associated Peptide; TGF-Beta-1; TGF-beta 1; TGFB; TGFB1; Transforming Growth Factor Beta-1
UniProt
P01137
Accession Number
P01137
Expression System
CHO Stable Cells
Tag
None
Sequence
Ala279-Ser390
Applications
Cell culture
Field of Research
Signal Transduction; Cell biology; Cardiovascular; Cancer; metabolism; Stem cells
Endotoxin
< 0.01 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Measured by its ability to inhibit the IL-4-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 4-40 pg/ml
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
12.8 kDa
Observed Molecular Weight
13 kDa
Species
Human
Available Sizes
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