Recombinant Human IL1F5/IL36RN Protein

Interleukin-1 family member 5 (IL-1F5) ; also known as interleukin 36 receptor antagonist (IL36RA) ; is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family; member 6 (IL1F6) . IL-1F5 is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9) . IL-1F5 could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A) ; beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1) ; which is present in epithelial barriers and takes part in local inflammatory response. It has been proved that IL-1F5 induces IL-4 mRNA and protein expression in glia in vitro and enhances hippocampal expression of IL-4 following intracerebroventricular injection. The inhibitory effect of IL-1F5 on LPS-induced IL-1β is attenuated in cells from IL-4-defective mice. Experiment results suggest that IL-1F5 mediates anti-inflammatory effects through its ability to induce IL-4 production and that this is a consequence of its interaction with the orphan receptor; single Ig IL-1R-related molecule (SIGIRR) /TIR8; as the effects were not observed in SIGIRR− /− mice. In contrast to its effects in brain tissue; IL-1F5 did not attenuate LPS-induced changes; or up-regulated IL-4 in macrophages or dendritic cells; suggesting that the effect is confined to the brain.

FIL; UNQ; PRO; IL1F; IL1L; IL1HY; IL1RP; PSORS; IL36RN; FIL1; FIL1 (DELTA) ; FIL1D; IL-36Ra; IL1F5; IL1HY1; IL1L1; IL1RP3; IL36RA; PSORP; PSORS14; UNQ1896; PRO4342; FIL1 Delta; IL-1 Delta; IL-1F5; IL-1HY1; IL-1L1; IL-1ra Homolog 1; IL-1-Related Protein 3; IL-1RP3; Interleukin-1 Delta; Interleukin-1 Family Member 5; Interleukin-1 HY1; Interleukin-1 Receptor Antagonist Homolog 1; Interleukin-1-Like Protein 1; Interleukin-36 Receptor Antagonist Protein

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.