Recombinant Human S100A2 Protein (Fc Tag)

The calcium-binding Protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21; and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney; and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium; and the active form functions in regulating cell proliferation and differentiation; gene transcription; and p53-dependent growth arrest and apoptosis. Accordingly; this protein is regarded as a putative tumor suppressor; and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.