Recombinant Human CD147/Basigin Protein

CD147/EMMPRIN (Extracellular Matrix Metalloproteinase Inducer) ; also known as Basigin (BSG) ; is a transmembrane glycoprotein with different forms resulted from different modes of glycosylation and N-terminal sequence variants. It is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermatogenesis; embryo implantation; neural network formation. CD147 induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells; and thereby promotes invasion; metastasis; growth and survival of malignant cells. Furthermore; CD147 also serves as a receptor for extracellular cyclophilinthe and its association with integrins might be important in signal transduction. Recently; CD147 displays increased expression in many cancers; and it has been previously demonstrated to participate in cancer metastasis and progression. Thus; CD147 and its antibody are used as an effective treatment for malignant cancers.

5F7; BSG; Basigin; CD147; Collagenase Stimulatory Factor; EMMPRIN; Extracellular Matrix Metalloproteinase Inducer; Leukocyte Activation Antigen M6; OK Blood Group Antigen; TCSF; Tumor Cell-Derived Collagenase Stimulatory Factor

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.