Recombinant Human JAM-A/F11R Protein (His Tag)

Junctional adhesion molecule-A (JAM-A) ; also known as F11 receptor (F11R) or Cluster of Differentiation 321 (CD321) ; is a transmembrane protein expressed at tight junctions of epithelial and endothelial cells; as well as on circulating leukocytes. JAM-A protein serves as a serotype-independent receptor for mammalian orthoreoviruses (reoviruses) . It is also a ligand for the integrin LFA1; involves in leukocyte transmigration. As a cell adhesion molecule of the immunoglobulin superfamily; JAM-A protein involves in platelet adhesion; secretion and aggregation; and plays a crucial role in inflammatory thrombosis and atherosclerosis. In addition; it may be a potential therapeutic target for breast cancer.

CD321; F11R; JAM-1; JAM-A; JAM1; JAMA; JCAM; Junctional Adhesion Molecule 1; Junctional Adhesion Molecule A; KAT; PAM-1; Platelet Adhesion Molecule 1; Platelet F11 Receptor

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.