Recombinant Human METAP1 Protein (Fc Tag)
Product Specifications
Background
Processing of the N-terminal initiator methionine or formylated methionine is an essential cellular process conserved from prokaryotes to eukaryotes. The proteolytic removal of N-terminal methionine from nascent peptides is catalyzed by a family of enzymes known as methionine aminopeptidases (MetAPs) and is essential for cell growth. METAP1 and METAP2 have different substrate specificity due to the differences in both size and shape of the active sites. As a member of the M24 family of metalloproteases, METAP1 plays an important role in G (2) /M phase regulation of the cell cycle and may serve as a promising target for the discovery and development of new anticancer agents.
Synonyms
MAP 1; MAP1A; METAP1; MetAP 1; MetAP1A; Methionine aminopeptidase 1; Peptidase M 1
UniProt
P53582
Accession Number
NP_055958.2
Expression System
HEK293 Cells
Tag
N-hFc
Sequence
Met 1-Phe 272
Field of Research
Signal Transduction; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 85 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/ochms8
Product MSDS
https://789.bio/eb/mrjH4S
Calculated Molecular Weight
57.0 kDa
Observed Molecular Weight
60-65 kDa
Species
Human
Curated Selection
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