Recombinant Human TGFBI/BIGH3 Protein (His Tag)
Product Specifications
Background
TGFBI is an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. TGFBI plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. TGFBI is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in TGFBI are associated with multiple types of corneal dystrophy. TGFBI can bind to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, TGFBI may be involved in endochondral bone formation. Loss of the TGFBI is sufficient to induce specific resistance.
Synonyms
BIGH3; CDB1; CDG2; CDGG1; CSD; CSD1; CSD2; CSD3; EBMD; LCD1
UniProt
Q15582
Accession Number
NP_000349.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-His 683
Field of Research
Signal Transduction; Neuroscience; Developmental Biology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 75 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/4dqhgo
Product MSDS
https://789.bio/eb/WnP08C
Calculated Molecular Weight
74.0 kDa
Observed Molecular Weight
65 kDa
Species
Human
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