Recombinant Human IL1F6/IL36A Protein (His Tag)

Interleukin-1 family member 6 (IL-1F6) ; also known as interleukin 36; alpha (IL36A) ; is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8; in addition to IL-1F9; activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta; suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line; NCI/ADR-RES; which naturally expresses IL-1Rrp2; all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6; IL-1F8; and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6; IL-1F8; and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.

FIL; IL1F; Interleukin-1 Family Member; IL-1F; IL36A; FIL1; FIL1 (EPSILON) ; FIL1E; IL-1F6; IL1 (EPSILON) ; IL1F6; FIL1 Epsilon; IL-1 Epsilon; Interleukin-1 Epsilon; Interleukin-1 Family Member 6; Interleukin-36 Alpha; IL1E; IL 1 epsilon; IL 1F6; IL 1H1; IL1RP2; Interleukin 1 epsilon; Interleukin 1 family member 6; Interleukin 1 family member 6 (epsilon) ; Interleukin 36 alpha; MGC129552; MGC129553; MGC151479; MGC151481; OTTMUSP00000012798; RP23-176J12.4

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.