Recombinant Human CD80/B7-1 Protein

The B-lymphocyte activation antigen B7-1 (referred to as B7) ; also known as CD80; is a member of cell surface immunoglobulin superfamily and is expressed on the surface of antigen-presenting cells including activated B cells; macrophages and dendritic cells. As costimulatory ligands; B7-1 which exists predominantly as dimer and the related protein B7-2; interact with the costimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells; and thus constitute one of the dominant pathways that regulate T cell activation and tolerance; cytokine production; and the generation of CTL. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.