Recombinant Human Coagulation Factor IX/F9 Protein (His Tag)
Product Specifications
Background
Coagulation factor IX, also known as Christmas factor, Plasma thromboplastin component and PTC, is a secreted protein which belongs to the peptidase S1 family. Coagulation factor IX / F9 contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. Coagulation factor IX / F9 is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca2+ons, phospholipids, and factor VIIIa. Defects in Coagulation factor IX / F9 are the cause of thrombophilia due to factor IX defect which is a hemostatic disorder characterized by a tendency to thrombosis. Defects in Coagulation factor IX / F9 are also the cause of recessive X-linked hemophilia B (HEMB) which also known as Christmas disease.
Synonyms
Christmas factor; Coagulation factor 9; Coagulation factor IX; Coagulation factor IXa heavy chain; Coagulation factor IXa light chain; F9; FIX; HEMB; P19; PTC; Plasma thromboplastin component; THPH8
UniProt
P00740
Accession Number
AAB59620.1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-Thr 461
Applications
Enzyme
Field of Research
Cardiovascular, Immunology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Measured by its ability to cleave the peptide substrate, Z-D-Arg-Gly-Arg-pNA. The specific activity is > 20pmols/min/ug.
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/cv9xu5
Product MSDS
https://789.bio/eb/H84S04
Calculated Molecular Weight
50.0 kDa
Observed Molecular Weight
60-80 kDa
Species
Human
Curated Selection
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