Recombinant Human CD300a/LMIR1 Protein (Fc Tag)

CMRF35-like molecule 8; also known as CD300 antigen-like family member A; CMRF35-H9; Immunoglobulin superfamily member 12; Inhibitory receptor protein 60; NK inhibitory receptor; CD300a and CMRF35H; is a single-pass type I membrane protein which belongs to theCD300 family. The CD300 family of myeloid immunoglobulin receptors includes activating (CD300b; CD300e) and inhibitory members (CD300a; CD300f) ; as well as molecules presenting a negative charge within their transmembrane domain (CD300c; CD300d) . CD300A / IGSF12 is expressed not only by natural killer (NK) cells but also by T-cell subsets; B-cells; dendritic cells; mast cells; granulocytes and monocytes.It contains oneIg-like V-type (immunoglobulin-like) domain. CD300A / IGSF12 is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells; and to the down-regulation of mast cell degranulation. CD300c is a functional immune receptor able to deliver activating signals upon ligation in RBL-2H3 mast cells. CD300c signaling is partially mediated by a direct association with the immune receptor tyrosine-based activation motif-bearing adaptor FcεRγ. CD300a and CD300c play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from plasmacytoid dendritic cells (pDCs) .

CD300 Antigen-Like Family Member A; CD300A; CD300a; CLM-8; CMRF-35-H9; CMRF35-H; CMRF35-H9; CMRF35-Like Molecule 8; CMRF35H; IGSF12; IRC1/IRC2; IRp60; IgSF12; Immunoglobulin Superfamily Member 12; Inhibitory Receptor Protein 60; NK Inhibitory Receptor

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.