Recombinant Human LRP10 Protein (His Tag)
Product Specifications
Background
Various members of the low-density lipoprotein receptor (LDLR) family have been reported to play a role in APP trafficking and processing and are important risk factors in AD.LDLR-related protein 1 (LRP1) shuttles between the trans-Golgi Network (TGN) ; plasma membrane (PM) ; and endosomes.LRP1 is a functional APP receptor involved in APP trafficking and processing. LRP1 interacts directly with the ectodomain of APP and colocalizes with APP at the TGN. LRP1 is a novel APP sorting receptor that protects APP from amyloidogenic processing; suggesting that a decrease in LRP1 function may contribute to the pathogenesis of Alzheimer's disease.
Synonyms
LRP9; MST087; MSTP087
UniProt
Q7Z4F1
Accession Number
Q7Z4F1-1
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-Lys 440
Field of Research
Stem Cells, Cardiovascular
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 97 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/9dihoc
Product MSDS
https://789.bio/eb/jrT00S
Calculated Molecular Weight
47.5 kDa
Observed Molecular Weight
60 kDa
Species
Human
Curated Selection
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