Recombinant Human Annexin A8/ANXA8 Protein (His Tag)
Product Specifications
Background
DPEP2 (MBD-2) belongs to the membrane-bound dipeptidase family. There are three members of this family as membrane-bound dipeptidase-1 (MBD-1), membrane-bound dipeptidase-2 (MBD-2) and membrane-bound dipeptidase-3 (MBD-3) .MBD-2 is expressed at highest levels in lung, heart, and testis and at some what lower levels in spleen.MBD-2 is membrane-bound through a glycosylphosphatidyl-inositol linkage and probably is a metalloprotease which hydrolyzes leukotriene D4 (LTD4) into leukotriene E4 (LTE4) .It is generally recognized that rapid cleavage of LTD4 is important in inactivating the broncho-and vaso-constrictive effects of cysteinyl LTs in asthmatic and inflammatory processes.
Synonyms
ANX8; ANXA8; Annexin A8; Annexin VIII; Annexin-8; VAC-Beta; Vascular Anticoagulant-Beta
UniProt
P13928
Accession Number
AAH73755.1
Expression System
E.coli
Tag
N-His
Sequence
Met 1-Pro327
Field of Research
Cardiovascular, Signal Transduction
Endotoxin
Please contact us for more information.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
39.1 kDa
Observed Molecular Weight
35 kDa
Species
Human
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