Recombinant Human ALK-2/ACVR1 Protein (Baculovirus, His Tag)
Product Specifications
Background
ALK-2; also termed as ACVR1; was initially identified as an activin type I receptor because of its ability to bind activin in concert with ActRII or ActRIIB. ALK-2 is also identified as a BMP type I receptor. It has been demonstrated that ALK-2 forms complex with either the BMP-2/7-bound BMPR-II or ACVR2A /ACVR2B. ALK-1 and ALK-2 presenting in the yeast Saccharomyces cerevisiae are two haspin homologues. Both ALK-1 and ALK-2 exhibit a weak auto-kinase activity in vitro; and are phosphoproteins in vivo. ALK-1 and ALK-2 levels peak in mitosis and late-S/G2. Control of protein stability plays a major role in ALK-2 regulation. The half-life of ALK-2 is particularly short in G1. Overexpression of ALK-2; but not of ALK-1; causes a mitotic arrest; which is correlated to the kinase activity of the protein. This suggests a role for ALK-2 in the control of mitosis. Endoglin is phosphorylated on cytosolic domain threonine residues by the TGF-beta type I receptors ALK-2 and ALK-5 in prostate cancer cells. Endoglin did not inhibit cell migration in the presence of constitutively active ALK-2. Defects in ALK-2 are a cause of fibrodysplasia ossificans progressiva (FOP) .
Synonyms
ACTR-I; ACVR1; ACVR1A; ACVRLK2; ALK-2; ALK2; Activin Receptor Type I; Activin Receptor Type-1; Activin Receptor-Like Kinase 2; FOP; SKR1; Serine/Threonine-Protein Kinase Receptor R1; TGF-B Superfamily Receptor Type I; TSR-I
UniProt
Q04771
Accession Number
Q04771
Expression System
Baculovirus-Insect Cells
Tag
C-His
Sequence
Met 1-Val 124
Field of Research
Signal Transduction; epigenetics and nuclear signal; Stem cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 93 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
12.8 kDa
Observed Molecular Weight
17 kDa
Formulation
Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol
Species
Human
Available Sizes
Curated Selection
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