Recombinant Human CSNK1A1/CKI-alpha/CK1 Protein (GST Tag)
Product Specifications
Background
Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are useful prognosis markers in non-small cell lung cancer (NSCLC) patients after complete resection, independent of lymph node metastasis status. CSNK1A1 can phosphorylate a large number of proteins. It participates in Wnt signaling. It phosphorylates CTNNB1 at 'Ser-45'. CSNK1A1 may play a role in segregating chromosomes during mitosis.
Synonyms
CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1; PRO2975
UniProt
P48729
Accession Number
P48729-1
Expression System
Baculovirus-Insect Cells
Tag
N-GST
Sequence
Met 1-Phe 337
Applications
Enzyme
Field of Research
Signal Transduction, Stem Cells
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
The specific activity was determined to be 30 nmol/min/mg using casein as substrate.
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
65.2 kDa
Observed Molecular Weight
62 kDa
Formulation
Supplied as sterile solution of 20mM Tris, 500mM NaCl, 2mM GSH, pH 7.4
Species
Human
Documents
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