Recombinant Human GALK1/Galactokinase Protein (His & GST Tag)
Product Specifications
Background
Galactokinase; also known as Galactose kinase; GALK and GALK1; is a protein which belongs to theGHMP kinase family and GalK subfamily. Galactokinase / GALK1 is a major enzyme for galactose metabolism. Galactokinase (GALK) deficiency is an autosomal recessive disorder characterized by elevation of blood galactose concentration and diminished galactose-1-phosphate; leading to the production of galactitol. Defects in GALK1 are the cause of galactosemia II (GALCT2) which II is an autosomal recessive deficiency characterized by congenital cataracts during infancy and presenile cataracts in the adult population. The cataracts are secondary to accumulation of galactitol in the lenses.
Synonyms
GALK; GALK1; Galactokinase; Galactose Kinase
UniProt
P51570
Accession Number
P51570
Expression System
Baculovirus-Insect Cells
Tag
N-His-GST
Sequence
Met 1-Leu 392
Field of Research
Signal Transduction; Cell biology; Cancer; epigenetics and nuclear signal; metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 90 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
70.0 kDa
Observed Molecular Weight
60 kDa
Formulation
Supplied as sterile solution of 20mM Tris, 500mM NaCl, 2mM GSH, pH 8.0
Species
Human
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