Recombinant Human TLK1/PKU-beta Protein (His & GST Tag)
Product Specifications
Background
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms
KIAA0137; PKU-beta
UniProt
Q9UKI8
Accession Number
Q9UKI8-1
Expression System
Baculovirus-Insect Cells
Tag
N-His-GST
Sequence
Met 1-Tyr 766
Applications
Enzyme
Field of Research
Epigenetics and Nuclear Signaling, Signal Transduction
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 88 % as determined by reducing SDS-PAGE.
Bioactivity
The specific activity was determined to be 1. 6 nmol/min/mg using Histone H3 protein as substrate.
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
114 kDa
Observed Molecular Weight
125 kDa
Formulation
Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 7.4, 10% glycerol
Species
Human
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