Recombinant Human IHPK1 Protein (His & GST Tag)
Product Specifications
Background
IHPK1 is a inositol hexaphosphate kinase (IHPK) protein which belongs to the inositol phosphokinase (IPK) family. IHPK proteins are likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) . IHPK1 may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. During cell death, IHPK1 activity is enhanced, and intracellular InsP7 level is augmented. The distribution of IHPK1 or another predisposing gene affected by position effect of translocation may explain the T2DM phenotype at least in this family.
Synonyms
IHPK1; PiUS
UniProt
Q92551
Accession Number
Q92551-1
Expression System
Baculovirus-Insect Cells
Tag
N-His-GST
Sequence
Met 1-Gln 441
Field of Research
Signal Transduction, Metabolism
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 85 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
78.0 kDa
Observed Molecular Weight
88 kDa
Formulation
Supplied as sterile solution of 20mM Tris, 500mM NaCl, pH 8.0, 10% glycerol
Species
Human
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