Recombinant Human CD16b/FCGR3B Protein, Biotinylated

Product Specifications

Background

Low affinity immunoglobulin gamma Fc region receptor III-B; also known as Fc-gamma RIII-beta; FcR-10; IgG Fc receptor III-1; FCG3; FCGR3; CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activation. FCGR3B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

CAS Number

9000-83-3

Synonyms

CD16b and FCGR6B, FCG3, FCGR3, FCRIII, FCRIIIb, Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, Low affinity immunoglobulin gamma Fc region receptor III-B

UniProt

O75015

Accession Number

O75015-1

Host

E. coli

Origin Species

Human

Tag

None

Sequence

Met 18-Gly 193

Applications

ELISA

Field of Research

Immunology

Purity

> 90 % as determined by reducing SDS-PAGE.

Bioactivity

1. Measured by its ability to bind human IgG1 in a functional ELISA. 2. Labeling ratio of biotin to protein: 5. 51.

Reconstitution

Please refer to the printed manual for detailed information.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.