Recombinant Mouse Il6RA/CD126 protein (His tag)

Product Specifications

Background

Interleukin 6 receptor (IL-6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor. The low concentration of a soluble form of IL-6 receptor (sIL-6R) acts as an agonist of IL-6 activity. In the IL-6R/CD126/IL6R system, both a membrane-bound IL-6R and a sIL-6R protein are able to mediate IL-6 signals into the cells through the interaction of gp130. The resulting IL-6/sIL-6R protein complex is also capable of binding to gp130 and inducing intracellular signalling. Through this so-called 'trans-signalling' mechanism, IL-6 is able to stimulate cells that lack an endogenous mIL-6R. High levels of IL-6 and sIL-6R have been reported in several chronic inflammatory and autoimmune diseases as well as in cancer.

Abbreviation

Il6RA; CD126

Synonyms

MGC; Membrane glycoprotein; IL-6R-Alpha; IL6RQ; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC30256; CD126; gp80; IL6Q; IL-6R; IL-6R 1; IL-6R subunit alpha; IL-6R-1; Il6r; Il6ra; IL-6Rα IL-6RA; interleukin 6 receptor; Interleukin-6 receptor

UniProt

P22272

Accession Number

P22272

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Glu357

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.