Recombinant Mouse DKK1 protein (His tag)
Product Specifications
Background
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Plays a role in limb development, attenuates Wnt signaling in the developing limb to allow normal limb patterning.
Abbreviation
DKK1
Synonyms
Dickkopf-1; Dickkopf-related protein 1; Dkk-1; Dkk1; mDkk-1
UniProt
O54908
Accession Number
O54908
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-His272
Field of Research
Immunology
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
29.8 kDa
Observed Molecular Weight
40 kDa
Species
Mouse
Available Sizes
Documents
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
CS715023 5x 5 µm
Tissue FFPE Sections, Unknown tissue consistent with neuroendocrine origin
Sign In for Pricing
View Details 
