Recombinant Mouse DKK1 protein (His tag)
Product Specifications
Background
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity. Plays a role in limb development, attenuates Wnt signaling in the developing limb to allow normal limb patterning.
Abbreviation
DKK1
Synonyms
Dickkopf-1; Dickkopf-related protein 1; Dkk-1; Dkk1; mDkk-1
UniProt
O54908
Accession Number
O54908
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-His272
Field of Research
Immunology
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
29.8 kDa
Observed Molecular Weight
40 kDa
Species
Mouse
Available Sizes
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