Recombinant Human TGF beta 1 protein (His tag)
Product Specifications
Background
Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA) . TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.
Abbreviation
TGF beta 1
Synonyms
LAP; Latency-Associated Peptide; TGF-Beta-1; TGFB; TGFB1; Transforming Growth Factor Beta-1
UniProt
P01137
Accession Number
P01137
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-Ser390
Field of Research
Signal Transduction; Cell biology; Cardiovascular; Cancer; metabolism; Stem cells
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/dha9o0
Product MSDS
https://789.bio/eb/Kujr9G
Calculated Molecular Weight
42.8 kDa
Observed Molecular Weight
48 kDa
Species
Human
Available Sizes
Curated Selection
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