Recombinant Human AGER protein (His tag)
Product Specifications
Background
Advanced Glycosylation End Product-Specific Receptor (AGER) belongs to the immunoglobulin superfamily of cell surface molecules. It lies within the major histocompatibility complex (MHC) class III region on chromosome 6. Besides AGEs, AGER is also able to bind other ligands which is thought to result in pro-inflammatory gene activation. It is known that AGER serve as a mediator of both acute and chronic vascular inflammation in certain conditions such as atherosclerosis and in particular as a complication of diabetes. Furthermore, it plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.
Abbreviation
AGER
Synonyms
AGER; Advanced Glycosylation End Product-Specific Receptor; RAGE; Receptor for Advanced Glycosylation End Products
UniProt
Q15109
Accession Number
Q15109
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-Ala342
Field of Research
Cardiovascular; Neuroscience
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/9gpuq5
Product MSDS
https://789.bio/eb/G0WnnD
Calculated Molecular Weight
37.5 kDa
Observed Molecular Weight
45 kDa
Species
Human
Available Sizes
Curated Selection
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