Recombinant Human FGL1/HFREP1 protein (His tag)
Product Specifications
Background
Hepassocin, also known as hepatocyte-derived fibrinogen-related protein 1 (HFREP-1), is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3.
Abbreviation
FGL1; HFREP1
Synonyms
FGL1; Fibrinogen-like protein 1; HFREP-1; HP-041; Hepassocin; LFIRE-1
UniProt
Q08830
Accession Number
Q08830
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met1-Ile312
Field of Research
Cardiovascular
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
34.2 kDa
Observed Molecular Weight
35 kDa
Species
Human
Available Sizes
Frequently Asked Questions
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