Recombinant Human MMP-9 protein (His tag)
Product Specifications
Background
Matrix metallopeptidase 9 (MMP-9) is an enzyme encoded by the MMP9 gene. This protein, which is produced by normal alveolar macrophages and granulocytes, can be activated by 4-aminophenylmercuric acetate and phorbol ester and up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. MMP-9 is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, angiogenesis, bone development, wound healing, cell migration, learning and memory, as well as in pathological processes, such as arthritis, intracerebral hemorrhage, and metastasis.
Abbreviation
MMP-9
Synonyms
92 kDa gelatinase;92 kDa type IV collagenase; CLG4B; GELB; Gelatinase B; MANDP2; MMP9; Matrix metalloproteinase-9
UniProt
P14780
Accession Number
P14780
Expression System
HEK293 Cells
Tag
C-His
Sequence
Met 1-Asp 707
Field of Research
Signal Transduction; Cell biology; Cardiovascular; Cancer
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/iia9oo
Product MSDS
https://789.bio/eb/LWDaP0
Calculated Molecular Weight
77.7 kDa
Observed Molecular Weight
85 kDa
Species
Human
Available Sizes
Curated Selection
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