Recombinant Human Arresten/COL4α1 protein (His tag)
Product Specifications
Background
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation.
Abbreviation
Arresten; COL4α1
Synonyms
Arresten; COL4A1; Collagen alpha-1 (IV) chain
UniProt
P02462
Accession Number
P02462
Expression System
HEK293 Cells
Tag
C-His
Sequence
Ser1441-Thr1669
Field of Research
Signal Transduction; cancer
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
25.1 kDa
Observed Molecular Weight
30 kDa
Species
Human
Available Sizes
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