Recombinant Human Apolipoprotein (a) /Lp (a) protein (His tag)
Product Specifications
Background
Apo (a) is the main constituent of lipoprotein (a) (Lp (a) ) . It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp (a) may be a ligand for megalin/Gp 330.Apo (a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp (a) . Apo (a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin (ogen) binding.
Abbreviation
Apolipoprotein; Lp
Synonyms
APOA; Apo (a) ; Apolipoprotein (a) ; LPA; Lp (a)
UniProt
P08519
Accession Number
P08519
Expression System
HEK293 Cells
Tag
C-His
Sequence
Asp1719-Arg2038
Field of Research
Cardiovascular, Neuroscience, Signal Transduction, Metabolism
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 95% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/vqmwwl
Product MSDS
https://789.bio/eb/W1qLmT
Calculated Molecular Weight
35.1 kDa
Observed Molecular Weight
35 kDa
Species
Human
Available Sizes
Curated Selection
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