Recombinant Human Apolipoprotein (a) /Lp (a) protein (His tag)

Apo (a) is the main constituent of lipoprotein (a) (Lp (a) ) . It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp (a) may be a ligand for megalin/Gp 330.Apo (a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp (a) . Apo (a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin (ogen) binding.

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.