Recombinant Human GITRL protein (His tag)
Product Specifications
Background
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1.Promotes leukocyte adhesion to endothelial cells .Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Abbreviation
GITRL
Synonyms
AITRL; Activation-inducible TNF-related ligand; Glucocorticoid-induced TNF-related ligand; hGITRL
UniProt
Q9UNG2
Accession Number
Q9UNG2
Expression System
HEK293 Cells
Tag
C-His
Sequence
Leu49-Ser177
Field of Research
Immunology, Tags & Cell Markers, Signal Transduction, Cancer, Cardiovascular
Endotoxin
< 1.0 EU/mg of the protein as determined by the LAL method.
Purity
> 90% as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Product Datasheet
https://789.bio/ea/uue90g
Product MSDS
https://789.bio/eb/8KyX98
Calculated Molecular Weight
14.6 kDa
Observed Molecular Weight
15 kDa
Species
Human
Available Sizes
Curated Selection
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