Recombinant Human IL-1α Protein

Product Specifications

Background

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

Abbreviation

IL-1α

Synonyms

IL1F; IL1A; IL-1A; IL1; IL1-ALPHA; IL1F1; BAF; FAF; Hematopoietin 1; Hematopoietin-1; IL 1 alpha; IL 1A; IL1 ALPHA; IL-1 alpha; IL1-A; Interleukin 1 alpha; Interleukin1 alpha; Interleukin-1 alpha; LAF; LEM; Preinterleukin 1 alpha; Pro interleukin 1 alpha; Pro-Interleukin-1-Alpha

UniProt

P01583

Accession Number

P01583

Expression System

HEK293 Cells

Tag

C-His

Sequence

Met1-Ala271

Field of Research

Cancer; Cardiovascular; Immunology

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 90% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.