Recombinant Human PD-L2/CD273 Protein (His Tag)

Product Specifications

Background

Programmed Cell Death 1 Ligand 2 (PDCD1LG2) is a member of the BTN/MOG family. PDCD1LG2 contains one Ig-like C2-type domain and one Ig-like V-type domain. PDCD1LG2 is highly expressed in the heart, placenta, pancreas, lung and liver, it is weakly expressed in the spleen, lymph nodes, and thymus. PDCD1LG2 is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PDCD1LG2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Abbreviation

PD-L2; CD273

Synonyms

B7-DC; B7DC; Butyrophilin B7-DC; CD273; PD-1 Ligand 2; PD-L2; PDCD1 Ligand 2; PDCD1L2; PDCD1LG2; PDL2; Programmed Cell Death 1 Ligand 2; Programmed Death Ligand 2

UniProt

Q9BQ51

Accession Number

Q9BQ51

Expression System

HEK293 Cells

Tag

C-His

Sequence

Leu20-Pro219

Field of Research

Immunology

Endotoxin

< 1.0 EU/mg of the protein as determined by the LAL method.

Purity

> 95% as determined by reducing SDS-PAGE.

Bioactivity

Not validated for activity

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis.

Shipping Conditions

This product is provided as lyophilized powder which is shipped with ice packs.

Storage Conditions

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.