Zerencotrep
Pico145 (HC-608) is a remarkable inhibitor of TRPC1/4/5 channels, inhibits (-) -englerin A-activated TRPC4/TRPC5 channels, with IC50s of 0.349 and 1.3 nM in cells, and shows no effect on TRPC3, TRPC6, TRPV1, TRPV4, TRPA1, TRPM2, TRPM8[1].
Product Specifications
CAS Number
[1628287-16-0]
Product Name Alternative
Pico145; HC-608
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pico145.html
Purity
99.47
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1C2=C(N=C(OC3=CC=CC(OC(F)(F)F)=C3)N2CC4=CC=C(Cl)C=C4)N(C)C(N1CCCO)=O
Molecular Formula
C23H20ClF3N4O5
Molecular Weight
524.88
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
