NOX2/gp91phox Polyclonal Antibody
Product Specifications
Background
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD) . In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
Abbreviation
NOX2/gp91phox
UniProt
P04839
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide of human NOX2/gp91phox
Target
AMCBX2; CGD; GP91-1; GP91-PHOX; GP91PHOX; IMD34; NOX2; p91-PHOX; CYBB
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Metabolism; Immunology
Purification
Affinity purification
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
65kDa
Observed Molecular Weight
65kDa
Isotype
IgG
Available Sizes
Documents
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