IWP-4

IWP-4 is a small molecule Wnt inhibitor with an IC50 of 25 nM.

Product Specifications

CAS Number

[686772-17-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/IWP-4.html

Purity

99.81

Solubility

DMSO : 1.72 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5OC)=O

Molecular Formula

C23H20N4O3S3

Molecular Weight

496.62

Precautions

H302

References & Citations

[1]Hudson J, et al. Primitive cardiac cells from human embryonic stem cells. Stem Cells Dev. 2012 Jun 10;21 (9) :1513-23.|[2]Frith JE, et al. Microbioreactor array screening of Wnt modulators and microenvironmental factors in osteogenic differentiation of mesenchymal progenitor cells. PLoS One. 2013 Dec 23;8 (12) :e82931.