FIT-039
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.
Product Specifications
CAS Number
[1113044-49-7]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
CDK; CMV; DNA/RNA Synthesis; HSV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fit-039.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC(NC(C2=CC=NC=C2)=S)=C(N3CCCCC3)C=C1
Molecular Formula
C17H18FN3S
Molecular Weight
315.41
Precautions
H302, H312, H332
References & Citations
[1]Makoto Yamamoto, et al. CDK9 Inhibitor FIT-039 Prevents Replication of Multiple DNA Viruses. J Clin Invest. 2014 Aug;124 (8) :3479-88.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9; HSV-1; HSV-2
Available Sizes
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