Luvixasertib (hydrochloride)
CFI-402257 hydrochloride is a highly selective and orally bioavailable TTK/Mps1 inhibitor with an IC50 of 1.7 nM for TTK in vitro. CFI-402257 hydrochloride has anti-cancer activity[1].
Product Specifications
CAS Number
[1610677-37-6]
Product Name Alternative
CFI-402257 (hydrochloride)
UNSPSC
12352005
Target
Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cfi-402257-hydrochloride.html
Purity
99.63
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=CC(C2=C3N=C(OC4=CN=CC=C4)C=C(NC[C@@H]5C[C@@](O)(C)C5)N3N=C2)=CC=C1C(NC6CC6)=O.Cl
Molecular Formula
C28H31ClN6O3
Molecular Weight
535.04
References & Citations
[1]Liu Y, et al. Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent. ACS Med Chem Lett. 2016 May 6;7 (7) :671-5.|[2]Mason JM, et al. Functional characterization of CFI-402257, a potent and selective Mps1/TTK kinase inhibitor, for the treatment of cancer. Proc Natl Acad Sci U S A. 2017 Mar 21;114 (12) :3127-3132.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Citation 01
Front Oncol. 2024 Aug 9:14:1447807.|bioRxiv. 2021 Feb 5.|bioRxiv. 2020 Apr. |Cancer Discov. 2019 Feb;9 (2) :230-247.|Commun Biol. 2021 May 24;4 (1) :617.|Oncol Rep. 2024 Aug;52 (2) :101.
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