Recombinant LRP1 Monoclonal Antibody
Product Specifications
Background
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712) . This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients.
Abbreviation
LRP1
UniProt
Q07954
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
A synthetic peptide of human LRP1
Target
LRP1; A2MR; APOER; APR; CD91; IGFBP3R; KPA; LRP; LRP1A; TGFBR5
Clonality
Monoclonal
Clone
R09-4E8
Conjugation
Unconjugated
Applications
WB; IHC-P
Field of Research
Neuroscience; Cardiovascular; Cell Biology; Signal Transduction; Metabolism; Cancer
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:1000-1:2000; IHC 1:20-1:100
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/h1pp0c
Product MSDS
https://789.bio/eb/XnH400
Calculated Molecular Weight
85kDa
Observed Molecular Weight
85kDa
Isotype
IgG
Available Sizes
Curated Selection
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