Recombinant Lamin A/C Monoclonal Antibody
Product Specifications
Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants.
Abbreviation
Lamin A/C
UniProt
P02545
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
A synthetic peptide of human Lamin A/C
Target
70 kDa lamin; Cardiomyopathy dilated 1A (autosomal dominant) ; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; Lamin A; Lamin A/C; Lamin A/C like 1; Lamin; Lamin C; Lamin-A/C; LDP1; LFP; LGMD1B; Limb girdle muscular dystrophy 1B (autosomal dominant) ; LMN 1; LMN A; LMN C; LMN1; LMNA; LMNA; LMNC; LMNL1; Prelamin A/C; PRO1; Renal carcinoma antigen NY REN 32; Renal carcinoma antigen NY-REN-32; Renal carcinoma antigen NYREN32
Clonality
Monoclonal
Clone
R07-1I5
Conjugation
Unconjugated
Applications
WB; IHC-P
Field of Research
Cancer; Signal Transduction; Tags and Cell Markers
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:1000-1:2000; IHC 1:50-1:100
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
74 kDa
Observed Molecular Weight
74/63 kDa
Isotype
IgG
Available Sizes
Documents
Curated Selection
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