Recombinant Cofilin Monoclonal Antibody
Product Specifications
Background
Cofilin is a ubiquitous actin-binding protein required for the reorganization of actin filaments. It is a member of ADF (actin-depolymerizing factor) /cofilin family that is a key regulator of actin dynamics and essential for cellular motility, cytokinesis, and endocytosis. Cofilin activity is tightly regulated by phosphorylation and dephosphorylation. Phosphorylation at Ser3 can inhibit its activity, also causing translocation from the nucleus to the cytoplasm.
Abbreviation
Cofilin
UniProt
P23528
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide of human Cofilin
Target
18 kDa phosphoprotein; CFL 1; CFL; CFL1; COF1; Cofilin 1; Cofilin 1 non muscle; Cofilin; Cofilin non muscle isoform; Cofilin-1; epididymis secretory protein Li 15; HEL-S-15; non-muscle isoform; p18
Clonality
Monoclonal
Clone
R06-2C0
Conjugation
Unconjugated
Applications
WB; IHC-P; IF
Field of Research
Cancer; Cardiovascular; Neuroscience; Signal Transduction
Purification
Affinity Purified
Concentration
300 μg/mL
Dilution
WB 1:500-1:1000; IHC 1:50-1:200; IF 1:50-1:100
Buffer
50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
19kDa
Observed Molecular Weight
19kDa
Isotype
IgG
Available Sizes
Documents
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